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Influenza A (H1N1) virus is a subtype of influenza A virus and was the most common cause of human influenza (flu) in 2009. Some strains of H1N1 are endemic in humans and cause a small. 1. J Virol. 2007 Aug;81(16):8766-73. Epub 2007 May 30. A mutation on influenza C virus M1 protein affects virion morphology by altering the membrane affinity of the protein.