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What are the symptoms and signs of acetaminophen-induced liver damage? What should be done if acetaminophen toxicity is suspected? Acetaminophen (Tylenol) Liver Damage At A Glance. Veterinarians currently employ two main strategies for managing pain in companion animals. The first strategy is pre-emptive analgesia. This involves giving pain medication. Acetaminophen is the most commonly used analgesic in the US, but has the potential to cause liver damage and failure. An FDA Advisory Committee has recommended reductions in the. Acute Acetaminophen Poisoning. To cause toxicity, an acute overdose must total ≥ 150 mg/kg (about 7.5 g in adults) within 24 h. Symptoms and Signs Acetaminophen Toxicity, Acetaminophen Overdose. Risk Factors: Serious to lethal hepatotoxicity Acetaminophen Overdosage Adults: 7.5 grams in 24 hours (or 150-250 mg/kg) Following an acute overdosage, toxicity may result from codeine or acetaminophen. Signs and Symptoms: Codeine: Toxicity from codeine poisoning includes the opioid triad of: pinpoint. Original Article from The New England Journal of Medicine -- Acetaminophen Toxicity in an Urban County Hospital.