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Barbiturate use can lead to both psychological and physical dependence and the drugs have a high abuse liability. [19] Psychological addiction to barbiturates can develop quickly. barbiturate , any one of a group of drugs that act as depressants on the central nervous system. High doses depress both nerve and muscle activity and inhibit oxygen consumption. BAR (Barbiturates) test is a simple one step immunochromatographic assay for the rapid, qualitative detection of barbiturates in urine. The cutoff of the test is 300 ng/ml of. Withdrawal from barbiturate dependence is itself is dangerous and potentially life-threatening. Depending on the length of use and the amount of the drug used, withdrawal symptoms.